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As research progresses, IGF-1 LR3 may continue to serve as a key compound in experimental models to understand fundamental biological processes and develop novel scientific approaches in cellular biology and tissue engineering

Stop MT2 entirely for 1014 days to allow MC1R surface expression to recover, then restart with a recalculated dose (0.01mg per kg body weight)

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However, chronic use is associated with: Motor fluctuations (wearing-off, onoff phenomena)

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*Correspondence: Shailendra Pratap Singh, [email protected] ORCID: sapna tiwari, orcid.org/0009-0000-5282-0324 Anjali Gupta, orcid.org/0009-0006-4759-9315 Deepa Pandey, orcid.org/0009-0005-0951-6761 Priyul Pandey, orcid.org/0009-0008-7084-2824 Rinkesh Gupta, orcid.org/0009-0006-9779-3618 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers