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In laboratory and animal studies, GLP-1 receptor agonists appear to reduce production of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1)

Musaro, A., McKullagh, K.J.A., Naya, F.J., Olson, E.N

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Switch to once weekly or monthly injections once desired outcome is achieved

Clinical translation would require trials in cardiac patient populations with appropriate safety monitoring given theoretical concerns about blood pressure effects and vascular remodeling

Most strikingly, multiple trials have now shown that GLP-1 agonists can lead to the resolution of MASH, a severe form of fatty liver disease, without worsening of liver fibrosis, which is a common adverse outcome seen with some current medications