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16 HerrmannW.SchorrH.ObeidR.GeiselJ

Dual GLP1 and GIP agonists Tirzepatide is a once weekly, subcutaneous, unimolecular dual RA (GLP-1 and GIP) which has comparable GIP receptor binding affinity to native GIP and 5 times lower GLP-1 receptor affinity than that of native GLP-1

Balancing the benefits and potential side effects of these medications will help you find the best treatment for your needs

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Recent phase 3 TRIUMPH4 data (Dec 2025) showed 28.7% loss over 68 weeks, exceeding semaglutide (1517.5%) and tirzepatide (22.5%)

Since GLP-1s also slow gastric emptying, the combination can lead to significant gastrointestinal discomfort