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Its predictable stability and well-characterized mechanism make it valuable across numerous laboratory models involving endocrine and metabolic pathways
Despite this, cyanocobalamin has been increasingly criticised in recent years, due to the following reasons: Toxicity: cyanocobalamin is often claimed to be toxic, as the cyano group form the poison cyanide
Whyte HJ, Baughman RD
See guidance from reputable medical sources such as Mayo Clinic and expert summaries like the one from the Cleveland Clinic that explain B12 injections are not a proven weight-loss therapy for people with normal levels
Hyperglycemia causes excessive glycation of sugars and unbound amino groups in proteins, which alters their physical and chemical characteristics (Feng et al., 2023)
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