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The last GSH synthetic process is the one depending on the conversion of the oxidized dimer GSSG to 2 reduced GSH molecules in cells by glutathione reductase (GR), an ubiquitous enzyme of the family of disulfide reductases, in the presence of NADPH and flavin adenine dinucleotide -FAD-

Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy

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Using MAGeCKflute CutoffCalling, we compared the gene hits by categorysensitizers (those whereby a loss sensitizes to 5FU) and resisters (those whose loss promote insensitivity to 5FU)and we observed several metabolic genes in both (Fig