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The SELECT trial, completed in 2023 with over 17,600 participants, showed a 20% reduction in cardiovascular events in patients with established cardiovascular disease and overweight or obesity without diabetes

Katz MD, Kligman I, Cai LQ, Zhu YS, Fratianni CM, Zervoudakis I, et al

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Insulin resistance is about too much sugar in the body

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Ankersen et al., PMID 9733495) anchor the adverse-event picture