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The trajectory follows a predictable pattern: rapid initial recovery, gradual tapering, eventual plateauing below the original baseline

Skipping doses or inconsistent timing

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All antibodies used for immunohistochemistry (IHC) are presented in Supplementary Table 6

Most melanotic macules are congenital, affect Caucasian individuals, may be single or multiple, have a diameter varying between 0.3cm and 3cm, tend to grow in proportion to the body growth, and are unrelated to any systemic condition