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Co-targeting menin and RAS in KMT2A-r/NPM1c AML with activated RTK signaling
In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity, thereby protecting the cells from reactive oxygen species and the products of peroxidation
doi: 10.1089/ars.2012.4785 26 LambethJD
No mathematical model can track all of the variables that might affect a complex biochemical system such as glutathione metabolism
Its also central to several biochemical pathways that cancer cells use to build new cell parts
copper accumulation from GHK-Cu is the main driver of the off period
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