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This systems-level knowledge has sparked increased interest in integrated therapy that combine microbiome manipulation with immune-targeted medicines to produce long-term disease improvement [184]

This indicates that maintenance sessions are needed to sustain the effect

Higher doses are also more likely to cause GI symptoms, such as bloating, gas, and diarrhea, because excess creatine may not be fully absorbed and can linger in the digestive tract, drawing in water and contributing to these uncomfortable side effects