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Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)
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Molecular size limits : GLP-1 is a peptide hormone with a molecular weight of about 3,300 daltons
For subcutaneous injection protocols, the concern is indirect: iron-induced copper depletion over weeks could lower the copper available for endogenous GHK-Cu (the body produces approximately 200 g/L of GHK in plasma that declines with age) [1]