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Higher therapeutic doses may warrant individualized guidance depending on skin response history

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While various risk factors for enhanced APAP toxicity have emerged in the numerous experimental models of steatosis, including induction of Cyp2E1, reduced phase II metabolism, mitochondrial dysfunction, etc., opposite effects have also been described, suggesting that steatosis may not affect toxicity [180]

All are described as rare, with real-world data placing serious digestive events in under one percent of users, though the post notes individual risk shifts with baseline health, comorbidities, and interactions with other medications

Neurosci Biobehav Rev 129:117

Perrott J, et al