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Int J Mol Sci 23(20)

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Clinical effects of regular dry sauna bathing: A systematic review

The Cochrane Collaboration: Review Manager (RevMan) [Computer program]

1 Introduction Alzheimers disease (AD) is a progressive and multifactorial neurodegenerative disorder that predominantly affects the elderly population, manifesting as severe cognitive decline, memory impairment, and behavioral disturbance (Tripathi et al., 2024)

Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide