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Instead of a single peak followed by a gradual decline, multiple smaller peaks create a more stable blood concentration throughout the week
Knop, F
To me, this suggests lower doses are placebo-like
Reading syringe markings correctly prevents dosing errors
Moreover, in a post hoc analysis of the SURPASS-4 randomized clinical trial, tirzepatide decreased albuminuria and total estimated glomerular filtration rate (eGFR) slopes and nearly halved the risk of a pre-specified composite kidney endpoint (eGFR decline 40%, renal death, kidney failure or new-onset macroalbuminuria) in participants with T2DM and high cardiovascular risk when compared with insulin glargine
