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(PubMed) Rahimdel A, Zeinali A, Yazdian-Anari P, Hajizadeh R, Arefnia E
Moderate - Both used in anti-aging skincare
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no published peer-reviewed stability trial sets a precise day count beyond this conservative window
Our previous work showed that CDKN2A expression is elevated in excitotoxicity-damaged RGCs and that CDKN2A knockdown ameliorates RGC death in mice 15
If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy
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