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A distinct nonclassical inflammasome pathway is triggered by direct binding of lipopolysaccharide (LPS) to caspase 11 (CASP11 in humans) or caspase 4/5 (CASP4/5 in mice), resulting in GSDMD cleavage [139]

14 February 2026

Activation of these pathways stimulates cellular proliferation and survival signaling, inhibiting apoptotic cell death and potentially promoting malignancy and carcinogenesis

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Unlike traditional cell therapies that require harvesting and re-engineering a patient's cells outside the body, Sail's platform is designed to reprogram immune cells directly inside the body, an approach the companies say could make CAR T manufacturing simpler and more scalable while delivering durable, potentially curative results

Austin Baraki, MD Austin Baraki is a practicing Internal Medicine physician, competitive lifter, and strength coach based in San Antonio, Texas