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L-carnitine exerts a nutrigenomic effect via direct modulation of nuclear receptor signaling in adipocytes, hepatocytes and SKMC, demonstrating its nutritional impact

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A 2025 review in Frontiers describing the research progress in the pathophysiological mechanisms of Type 2 diabetes framed this as an integrated picture

Discussion This review summarises: (1) appetite-related gut hormone changes after weight loss in people with overweight or obesity and (2) the differences among interventions involving CR, EX or their combination

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L-Glutamine has minimal risks, though high doses may strain kidneys in those with pre-existing conditions