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Prioritise self-care, adequate sleep, and stress management techniques

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Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice

The characteristically motif -PPPGKP- present in high frequency and periodically repetitive has been found in saliva by many investigators 9,10,11

Moreover, SHANK3 knock-out in mice demonstrated that SHANK3 is associated with total brain volume and hippocampal size [108]