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discovered that a decrease in GSH content is a potential early activation signal for apoptosis, with subsequently generated oxygen free radicals promoting the occurrence of apoptosis

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For example, overexpression of the transcription factor forkhead box o4 (FOXO4) in 3T3L1 cells inhibits CYP51A1 mRNA levels, leading to the intracellular accumulation of 24,25-dihydrolanosterol (DHL) and lanosterol

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