Its not recommended with uncontrolled hypertension, significant cardiovascular disease, hyperthyroidism, glaucoma, pregnancy, or with MAOIs
However, when taken intramuscularly, your body can totally bypass the gastrointestinal system, thereby decreasing the time it takes to reach your body as well as increasing your bodys ability to absorb the vitamin and all its benefits
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C.DussaillantG.RamosC.LenL.et al (2014)
Directions: 5 ml per 100 lbs body weight
The FDA differentiates between the two based on their approved uses, clinical trial data, and dosages