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When we stratified patients by history of renal disease, the use of the GLP-1 receptor agonist-SGLT-2 inhibitor combination in patients with a history of renal disease was associated with a lower hazard ratio for major adverse cardiovascular events (0.41, 0.18 to 0.94) compared with patients without previous renal disease (0.80, 0.57 to 1.12

Some of these products have not undergone sufficient human clinical trials and may cause significant harm

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The Metabolic Effects of GLP-1 GLP-1 medications can influence your metabolism in several ways [5]: Target hormones that regulate appetite and satiety Potentially promote the use of stored fat for fuel May slightly increase your basal metabolic rate Research suggests these medications might enhance metabolic rate and promote fat breakdown by activating specific enzymes and pathways involved in energy metabolism [12]

Categorical variables were compared using the chi-square test

Wu Y, Zhang D, Chu JY, Boyle P, Wang Y, Brindle I, DeLuca V, Desprs C