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31 Since the 2021 review, one more RCT has been published that compared oral B12 alone, 25 g per day (form not reported), or with folate (800 g per day) versus no supplements for 6 months in patients with mild cognitive impairment

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A marked, reproducible increase in sexual arousal

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In most people, a good quality B vitamin supplement, and not a shot, is probably the best solution

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Another concept is to measure B12 bound to the plasma protein transcobalamin (holoTC, active B12) before and after administration of three high physiological doses of B12 for two days

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