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Investigation of safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of a long-acting -MSH analog in healthy overweight and obese subjects

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In obese (OB/OB) mice, GLP-1 reduces ER stress in adipose tissue, improving insulin sensitivity through unresolved mechanisms (Yi et al., 2023)

You may be a candidate if: Your BMI is 30 or higher Your BMI is 27 or higher with a weight-related condition such as high blood pressure or type 2 diabetes Youve tried diet and exercise consistently without losing at least 5% of your body weight These medications may not be appropriate if you are pregnant or breastfeeding, under 18, or have certain medical conditions involving the pancreas, kidneys, or thyroid