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Although this study is based on real-world data in a representative population of people with type 2 diabetes, enhancing its external validity, the improvements in HbA 1c seen after introduction of tirzepatide were modest in comparison with those seen in clinical trials and may not be applicable in a population with less-optimised baseline glycaemic control

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Selecting T cell targets rather than neutralising B cell antigens also eliminates the possibility of antibody-dependent enhancement (ADE) through vaccination

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