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Reduction therefore dismantles the complex and liberates copper in its most redox-active form, which in an oxygenated, peroxide-containing environment participates in Fenton-type chemistry

It is unique because it can pass through the mitochondria and enter the nucleus of the cell, where it activates signals that promote normal metabolic homeostasis of glucose and lipid metabolism

Copper accumulation also becomes a theoretical concern at extreme doses, though practical protocols stay well below problematic thresholds

Two failure modes for this protocol are predictable