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However, GCL is upregulated by estradiol, leading to a higher concentration of glutamyl-cysteine (Glut-Cys) in females, thereby driving increased GS flux

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E1 is a thiamin pyrophosphate (TPP)-dependent -ketoacid dehydrogenase, R -lipoic acid functions as a prosthetic group essential for E2 transacetylase activity, and E3 is a flavin adenine dinucleotide (FAD)-dependent dihydrolipoamide dehydrogenase ( Figure 4 )

Drinking a lot of alcohol or taking certain medicines can also affect B12 absorption

Understanding these mechanisms provides the foundation for exploring therapeutic interventions that might support cellular health throughout the aging process