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The Pharmacodynamics, Pharmacokinetics, and Safety of Arhalofenate in Combination with Febuxostat When Treating Hyperuricemia Associated with Gout

210 The principles of Mendelian randomization, which leverages genetic variants influencing exposures (e.g., UA levels), can serve as a natural randomization method to study the causal effects of these exposures on disease outcomes

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Moreover, loss-of-function mutations of succinate dehydrogenase (SDH) increase cellular succinate level, which inhibits DNA demethylation and contribute to tumorigenesis [62,63]

The study cohort consisted of children diagnosed with either isolated GHD or idiopathic short stature

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