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A 2020 review in Diabetes Care noted that "the hypoglycaemic effect of IGF-1 has been exploited therapeutically in rare forms of insulin-receptor-defect syndromes, but the risk-benefit calculation differs fundamentally from use in euglycaemic individuals" [20]

At the highest dose, 57 percent of participants lost at least 20 percent of their body weight results that rival surgical outcomes

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In 2021, the FDA approved semaglutide (Wegovy) for chronic weight management in adults who are overweight or obese