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By safeguarding cell membranes, astaxanthin also makes it more possible for glutathione to work well as both a detoxifier and an antioxidant. After oxidation from neutralizing free radicals, glutathione can help improve oxidation-damaged astaxanthin

Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

xCT inhibitors can also have therapeutic benefits for ovarian cancer cells growing in a high-glucose tumor environment (e.g., ovarian cancer cells overexpressing SLC7A11, GLUT1, PDK, glutaminase, and GPX)

Current evidence supports indefinite use for patients who tolerate the medication well and continue to benefit from it