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Leptin, a key regulator of satiety and appetite, is decreased in active IBD, probably due to exhaustion after transient overproduction related to TNF- hyperactivity

Abstract Background Alogliptin belongs to gliptin family of drugs that inhibits ubiquitous enzyme dipeptidyl peptidase-4 (DPP-4)

The recent FLOW trial with semaglutide in patients with chronic kidney disease and T2DM, with a composite of major kidney disease events as the primary outcome, showed significant reductions in both cardiovascular mortality (HR 0.71

Larger trials on more diverse populations are needed [28]

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