In addition to weight loss, GLP-1RAs may affect lymphedema, given their beneficial effects on glucose control
Specifically, Saxenda is approved to treat adults with obesity and adolescents 12 years and older who weigh more than 60 kilograms (about 132 pounds) and have been diagnosed with obesity
Interestingly, the combination of semaglutide and trevogrumab alone (without garetosmab) was better tolerated, with discontinuation rates similar to semaglutide monotherapy, suggesting that garetosmab may contribute to the increased side effects in the triplet regimen
They also take up more space, if you need to travel and space is at a premium
If you have unused 2.5mg pens after escalating to 5mg, store them in the refrigerator
For example, the activation of Akt by phosphorylation can lead to the inhibition of apoptosis-promoting factors and the activation of factors involved in cell growth and metabolism-related processes [133]