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Essential baseline investigations typically include: Lipid profile : Total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides to establish baseline values HbA1c or fasting glucose : To screen for diabetes or prediabetes Liver function tests : As baseline measurement, particularly if considering long-term treatment Thyroid function tests : To exclude thyroid disorders that may affect weight Blood pressure measurement : To assess overall cardiovascular risk Renal function : Particularly important for patients on multiple medications Pregnancy test : Where appropriate, before starting treatment Cardiovascular risk assessment using tools such as QRISK3 helps determine the overall 10-year risk of cardiovascular disease
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When to Speak to a UK-Registered Healthcare Professional Anyone using or considering unlicensed peptides should consult a GMC-registered clinician
PMID 15523674
Semaglutide also carries a boxed warning about thyroid C-cell tumors occurring in rodents (with unknown risk in humans), and Semaglutide shouldnt be used if you or your family have a history of certain thyroid cancers
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