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The main drivers for weight regain after significant WL include the persistence of a lower resting metabolic rate and the increased appetite, possibly mediated through long lasting increased orexigenic and decreased anorexigenic signals [2, 6]

doi: 10.3390/stresses2010009 90 DudnikA.GasparP.NevesA

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Acta 1830 (6), 38463857

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Eligible individuals had not taken antidiabetic medications for at least 90 days, were insulin-naive, had an HbA 1C between 7.0% and 9.5%, and had a body mass index (BMI) of 23 kg/m 2