The biggest differences are how they are administered, how often you need to take them, and how effective they are
Chronic myelogenous leukemia, promyelocytic leukemia, polycythemia vera and hypereosinophilic syndrome have all been associated with high B12 levels (25)
This chart may be useful as an overview: What Are The Symptoms of Vitamin B12 Deficiency
Low B12 levels can lead to megaloblastic anemia, a condition where red blood cells are abnormally large and unable to transport oxygen efficiently, causing symptoms like fatigue, weakness, and breathlessness
In one large study involving 4,281 participants, researchers compared vitamin B12 levels in people receiving intramuscular injections with those taking sublingual methylcobalamin
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