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1 Introduction The advent of incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their combinations, as pharmacological treatments for obesity and type 2 diabetes, has sparked intense debate about their role relative to traditional lifestyle interventions such as exercise and dietary modification

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Alternatively, some people do better on a lower maintenance dose long term rather than pushing to the maximum dose

Sugar-free electrolyte-containing beverages may be beneficial if you have significant fluid losses, especially for patients with diabetes

Avoid in active malignancies, the protocol shouldnt exacerbate undiagnosed tumors

Interestingly, these drugs are also effective at reducing body weight [17, 18]