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Side Effects to Watch for When Switching From Tirzepatide to Retatrutide Because Retatrutide carries an added mechanism compared to Tirzepatide, some people experience new or different side effects during the transition

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BMI 30 or higher with heart failure with preserved ejection fraction, uncontrolled hypertension on two or more medications, or chronic kidney disease stage 3a or higher

Those are not interchangeable

In conclusion, combination of metformin and liraglutide has synergistic protective effects on endothelial function