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In addition to previously mentioned characteristics of Stage 3C, the following additional unpleasant symptoms commonly surface in this Phase: Bloating with gastric and jaw tightness after eating, and only small amounts of food or liquid can be tolerated at one time Extreme sensitivity to minute dose of iodine, Chineses herbs, glandular, Vitamin C, Vitamin B Extreme intolerance to most vegetables, especially those high in potassium Extreme nervousness and sense of impending doom Uncomfortable chest and head contractions when arising from a supine position Extreme sensitivity to gluten, wheat, and dairy products Extreme sensitivity to massage, acupuncture, sauna, detoxification, or stretching Extreme fluid and electrolyte imbalances such as dilutional hyponatremia and fragile blood pressure Extreme reliance on prescription medications for sleep Extreme temperature intolerance to heat such as sunlight, hot bath and cold such as passing by an open refrigerator, cool room, and cold water Shortness of breath when not lying down or if not concentrated on breathing Breathing ceases to become an automatic subconscious function but requires conscious energy Extreme high frequency of racing thoughts with the mind unable to stop and feeling continuously wired Extreme sensitivity to TV, computer monitor, telephone, cell phone, fluorescent lights, electric blanket, Wi-Fi signals Extreme overall weakness that impedes normal talking or eating Extreme and persistent constipation requiring enema to empty bowls Extreme cold hands and feet in a room where others feel normal Extreme sensitivity to chemicals in common household items such as perfume, shampoo, and other oil based products Extreme dry skin and hair Fatigue worsens with small dosage of steroidal medications such as Cortef or Florinef Extreme weight loss PMS type symptoms from day 4-14 of the menstrual cycle Extreme sensitivity to vibration (traveling in a car on a bumpy road) It is not uncommon to see a reversal of the 24-hour saliva cortisol curve pattern, with low cortisol in the morning and high in the late afternoon and evening

Selected Publications Jo, L., Pelletier, J.M., Hsu, S., Baden, R., Goldberg, R.B., Harada, J.J., "Combinatorial interactions of the LEC1 transcription factor specify diverse developmental programs during soybean seed development", Proc

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15 Further research is needed to identify effective targeted therapies and treatment strategies for MMNSTs

GLP-1 RAs Hold Promising Potential for Reduction of Cardiometabolic Risk Factors additional benefits : Brain: Appetite suppression, nerve protection, and decreased neuroinflammation Heart: Decreased blood pressure (systolic and diastolic), reduced total cholesterol levels, lowered endothelial dysfunction, and increased heart rate Liver: Decreased glucose production Pancreas: Increased insulin secretion, decreased glucagon secretion, B islet cell proliferation GI Tract: Decreased gastric emptying Because these drugs cause weight loss, it is not clear whether the GLP-1 RAs or the weight loss reduces cardiometabolic risks