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Via the 2AR-cAMP-PKA/NF-B pathway, PAGln promotes inflammatory cytokine transcription, as evidenced by increased NF-B phosphorylation and pro-inflammatory macrophage polarization in murine BMDMs following 24-h treatment with 100 M PAGln (Huang and Zhang, 2023)

Schisandra also improves symptoms of anxiety, depression and motor dysfunction