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For example, a meta-analysis of 31 randomized, controlled trials reports that the most common side effects observed in the hGH studies and their respective incidences were [16]: Soft tissue edema: 50% Insulin resistance: 22% Arthralgias: 21% Carpal tunnel syndrome: 19% These side effects are transient and usually subside as the patient gets used to the therapy

doi:10.1089/THY.2006.16.455 8

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Compensatory secretion of growth hormone/insulin and activation of InsR While growth hormone stimulates IGF1 synthesis, activation of IGF-IR/InsR by IGF feeds back to inhibit growth hormone synthesis [27]