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Some research also suggests that if you become vitamin B12 deficient, it can increase your risk of age-related macular degeneration (AMD), which is a gradual type of vision loss common in people over 50

5-Amino-1MQ selectively inhibits NNMT (IC50 = 1.2 M), an enzyme that consumes nicotinamide by methylating it

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In people without pernicious anemia, about 0.5 g/day of B12 is reabsorbed by enterohepatic circulation in which B12-containing bile is secreted by the liver into the digestive tract where the B12 is then reabsorbed via intrinsic factor

Vitamin C: Essential cofactor for collagen synthesis