A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

Before taking Vitamin B12 Injection, inform your doctor if you: Are allergic to Vitamin B12 or cobalt Have any other food or medicine allergies An eye disease called as Leber's optic neuropathy A slow growing blood cancer where your bone marrow makes too many red blood cells (polycythemia vera) Gout (high uric acid levels in body) Iron or folic acid deficiency anemia Low potassium levels in your blood Drug interactions It is important to tell your healthcare professional about all other medicines that you have taken recently including any kind of supplements and non-prescription drugs
Low B12 levels can lead to fatigue, weakness, mood changes, or even tingling in your hands and feet
Do B12 Injections Help with Fatigue
L-methymalonyl-CoA mutase converts L-methymalonyl-CoA to succinyl-CoA, which is essential for the metabolism of protein and fat
The concentration depends on how much BAC water you added