Front Pharmacol 2022;13:925377.ArticlePubMedPMC 55
Examples Repaglinide (Prandin) Dosage Initial: 0.52 mg before each meal, up to four times daily Maximum: 16 mg daily, 4 mg per dose Nateglinide (Starlix) Dosage Initial: 60120 mg before meals, up to three times daily Maximum: 360 mg daily, 120 mg per dose Possible side effects include: Hypoglycemia (lower risk than sulfonylureas) Weight gain Bile acid sequestrants Primary mechanism(s) of action Bile acid sequestrants were originally developed and approved to lower LDL-cholesterol
The idea is indeed interesting, but it isn't supported by the evidence
doi: 10.4078/jrd.2024.0054 39 ChenPLuoZLuCJianGQiXXiongH
Similarly, silymarin protected against ischemia-reperfusion injury, a pro-oxidative state and a major contributor to acute kidney injury, when given to rats at a dose equivalent to about 567 mg for an adult human (Senturk 2008)
Its bidirectional action means it absorbs excess water from loose stool, adding form and bulk
