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2.3 Failure of antioxidant system Nuclear factor erythroid 2-related factor 2 (NRF2) orchestrates cellular antioxidant defense by directly regulating glutathione (GSH) biosynthesis and GPX4 expression through transcriptional control of Glutamate-Cysteine Ligase Catalytic Subunit(GCLC)/ Glutamate-Cysteine Ligase Modifier Subunit(GCLM) and GPX4 (Fan et al., 2024)
The variation in nausea rates between different GLP-1 receptor agonists relates to several pharmacological and formulation factors
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