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Previous studies have found that ACSL4 catalyzes the activation of AA to AA-CoA, which can be utilized to generate 5-hydroxyeicosatetraenoic acid (5-HETE) by lipoxygenase (LOX), thus inducing ferroptosis via 5-HETE-mediated lipotoxicity [135]

Theyre like super-sized treatment options," says Dr

Catalase activity initially increased in both groups during early Dox exposure but later became suppressed as cumulative toxicity mounted, with a more profound decline in saline-treated rats

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But regular, prolonged use, even of mild steroids, can add up over months or years

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