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These receptor agonists are recognized for their cardioprotective properties and have been approved by the FDA to lower the risk of major adverse cardiovascular events in individuals who are overweight or obese with cardiovascular disease

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Retatrutide is an investigational triple agonist (GLP-1, GIP, and glucagon receptors) not yet licensed by the MHRA or EMA, with Phase 2 data suggesting significant weight reduction but Phase 3 confirmation still required

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Start at a lower dose and increase gradually to avoid gas or discomfort