GLP-1 agonists bring about similar degrees of weight loss regardless of psychiatric status, but there are reasons to think obesity is different in patients with psychiatric disorders
Headache worse lying down (the more common GLP-1 pattern): Suggests relative CSF volume depletion Brain is inadequately cushioned Lying down increases intracranial pressure, stretching pain-sensitive structures Standing allows CSF to drain, reducing pressure Fix: hydration to restore CSF volume Headache worse standing up (less common, but possible): Suggests CSF leak or severe volume depletion Brain sags downward when upright due to inadequate CSF support Lying down allows the brain to float properly again Standing creates traction on meninges and cranial nerves Fix: aggressive hydration, possible imaging to rule out CSF leak The GLP-1 pattern is usually the first type (worse lying down) because the mechanism is relative hypervolemia when supine in the context of chronic mild dehydration
And that's what happened here
During days 17 and 21, workout recovery was much faster
Wegovy works in part by slowing down digestion
This mechanism allows muscles to contract harder and recover faster between repetitions, which is why creatine has been shown to enhance strength gains and training volume
