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In the ATTAIN-MAINTAIN trial, 205 patients taking tirzepatide and 171 patients taking semaglutide were randomized to take orforglipron or placebo (no active drug) daily for a year
200,201 Metabolism-derived lactylation in turn regulates metabolism by enhancing gene transcription, particularly in cancer
Phentermine is a stimulant that works similarly to an amphetamine to reduce appetite, while topiramate is an anticonvulsant that can also decrease appetite
Finally, we presented our insights on clinical concerns such as appropriate trial endpoints, management of comorbidities, and future developments
Housing affordability can be measured using various methods, such as the price-to-income ratio (PIR), which is defined as the ratio of the median house price to the median household income in a city or country
Importantly, tirzepatide carries an FDA boxed warning for risk of thyroid C-cell tumors, and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
