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It could be that apparently healthy people who report benefits may have undiagnosed B12 deficiency
or female health professionals with known cardiovascular disease or vascular disease risk factors (WAFACS), recent stroke or transient ischemic attack (VITATOPS), or myocardial infarctions (SEARCH)
Heavier individuals may require higher doses to achieve equivalent NNMT inhibition due to larger adipose tissue mass and potentially higher baseline NNMT activity
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