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Cell Metab 30 , 987996.e6 (2019)

Using an animal model over a 21 day period, scientists observed several notable changes: A decline in beneficial gut bacteria that break down dietary fibre Lower levels of short chain fatty acids, which support the gut lining and help control inflammation Increased levels of inflammatory markers in the blood Greater liver weight, a possible sign of low grade inflammation A smaller cecum -- the part of the intestine where gut bacteria break down fibre and produce protective compounds Reduced levels of a brain derived protein associated with cognitive impairment The study does not prove that SNAC is harmful

[148] have highlighted the neuropsychiatric dimensions of GLP-1 RAs, including their potential relevance for relapse vulnerability and cognitive-affective regulation after pharmacotherapy discontinuation

Both require structured medical oversight for optimal results

Pearson-Stuttard J, Bennett J, Cheng YJ, Vamos EP, Cross AJ, Ezzati M, et al

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