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Building upon this core machinery, the glucosinolate pathway involves three additional enzymatic modules completing metabolic transformation: (1) CYP83A1 converts aliphatic aldoximes to thiohydroximates, (2) UGT74B1 mediates glycosylation of sulfated intermediates (requiring prior sulfation by SOT17/18), (3) the myrosinase-TGG1/2 system, in concert with epitope-specific proteins (ESPs), hydrolyzes stored glucosinolates into bioactive compounds like SFN upon tissue damage (41)

& McLeod, R

The two proteins have apparent DHAR activity and contain GSH, which appears to be covalently attached to the catalytic cysteine residue via a disulfide bond at the active site 11,20

TUNEL staining revealed the same levels of cell death in xenografts originating from GPX4-knockdown NPC cells and control cells (Fig

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Older adults : Older adults are more prone to developing vitamin B12 deficiency because stomach acid and intrinsic factor production naturally decline with age