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The latter, while providing valuable real-world signals, are inherently susceptible to confounding by indication and selection bias, as patient characteristics and co-morbidities may differ significantly between treatment groups

2.6% placebo) - Once-daily oral amycretin: 7.6% placebo-adjusted weight loss at 36 weeks - Significant HbA1c reductions with both formulations This is important because it shows both delivery routes working in the same population